Search results for "target [deuteron]"

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention

2014

// Nicole M. Davis 1 , Melissa Sokolosky 1 , Kristin Stadelman 1 , Stephen L. Abrams 1 , Massimo Libra 2 , Saverio Candido 2 , Ferdinando Nicoletti 2 , Jerry Polesel 3 , Roberta Maestro 4 , Antonino D’Assoro 5 , Lyudmyla Drobot 6 , Dariusz Rakus 7 , Agnieszka Gizak 7 , Piotr Laidler 8 , Joanna Dulinska-Litewka 8 , Joerg Basecke 9 , Sanja Mijatovic 10 , Danijela Maksimovic-Ivanic 10 , Giuseppe Montalto 11,12 , Melchiorre Cervello 12 , Timothy L. Fitzgerald 13 , Zoya N. Demidenko 14 , Alberto M. Martelli 15 , Lucio Cocco 15 , Linda S. Steelman 1 and James A. McCubrey 1 1 Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC 27858 USA 2 …

Investor Sentiment or Managerial Overconfidence: The Back Room of Acquisitions

2017

In this study, we investigate bidder performance (both in the short and the long term) in periods of high and low valuation market in response to announcements of acquisitions carried out by Spanish listed firms over the period 1991-2011. We provide evidence that bidder reaction to acquisitions, in both the short and the long term, is not consistent with the predictions of investor sentiment (optimism) after controlling for target type. However, our findings after controlling for bidder market-to-book ratio reveal under reaction in acquisitions of listed targets that is not independent of the market sentiment, since it is greater in hot periods. Finally, the results are not so consistent fo…

Greedy and K-Greedy algoritmhs for multidimensional data association

2011

[EN] The multidimensional assignment (MDA) problem is a combinatorial optimization problem arising in many applications, for instance multitarget tracking (MTT). The objective of an MDA problem of dimension $d\in\Bbb{N}$ is to match groups of $d$ objects in such a way that each measurement is associated with at most one track and each track is associated with at most one measurement from each list, optimizing a certain objective function. It is well known that the MDA problem is NP-hard for $d\geq3$. In this paper five new polynomial time heuristics to solve the MDA problem arising in MTT are presented. They are all based on the semi-greedy approach introduced in earlier research. Experimen…

The COMPASS Setup for Physics with Hadron Beams

2015

The main characteristics of the COMPASS experimental setup for physics with hadron beams are described. This setup was designed to perform exclusive measurements of processes with several charged and/or neutral particles in the final state. Making use of a large part of the apparatus that was previously built for spin structure studies with a muon beam, it also features a new target system as well as new or upgraded detectors. The hadron setup is able to operate at the high incident hadron flux available at CERN. It is characterised by large angular and momentum coverages, large and nearly flat acceptances, and good two and three-particle mass resolutions. In 2008 and 2009 it was successful…

Automated Measurement of Microcirculatory Blood Flow Velocity in Pulmonary Metastases of Rats

2014

Because the lung is a major target organ of metastatic disease, animal models to study the physiology of pulmonary metastases are of great importance. However, very few methods exist to date to investigate lung metastases in a dynamic fashion at the microcirculatory level, due to the difficulty to access the lung with a microscope. Here, an intravital microscopy method is presented to functionally image and quantify the microcirculation of superficial pulmonary metastases in rats, using a closed-chest pulmonary window and automated analysis of blood flow velocity and direction. The utility of this method is demonstrated to measure increases in blood flow velocity in response to pharmacologi…

Calidad de la farmacoterapia y seguridad de los pacientes en hemodiálisis tratados con estimulantes eritropoyéticos

2008

Objective: To assess an interdisciplinary programme for the improvement of pharmacotherapy quality and patient safety in patients with chronic renal disease who are treated with erythropoiesis-stimulating agents. Method: Observational, longitudinal study. Retrospective analysis (period A) and prospective analysis (period B) following implementation of the programme for haemoglobin values and monthly erythropoiesis- stimulating agent dosage. The proportion of patients with haemoglobin values within the target range (10-5-12.5 g/dl) and those with values above the safety limit (≥ 12.5g/dl) were compared every four months and the average percentage of time with haemoglobin values within the ta…

A facility for fast-neutron irradiations at Jyväskylä and its use for nuclide cross-section measurements in fission

2013

Abstract An efficient and reliable transport system for fast-neutron irradiations has been built at the Physics Department, Jyvaskyla, Finland. It is constructed from commercial bicycle components and is driven by a computer-controlled stepping motor. It can be operated in single or cyclic mode. The neutron irradiated targets are moved within 1.2 s (full stop to full stop) to a well-shielded position 3 m away where they can be removed or directly investigated by γ spectroscopy. The system has been built with the aim to experimentally verify the calculated production rates of neutron-rich nuclei in the SPIRAL2 uranium target. However, the facility can be used for various kinds of fast-neutro…

Temperature-toxicity relationships of fluvalinate (synthetic pyrethroid) on Procambarus clarkii (Girard) under laboratory conditions.

1988

An adaptive approach to learning the preferences of users in a social network using weak estimators

2012

Published version of an article in the journal: Journal of Information Processing Systems. Also available from the publisher at: http://dx.doi.org/10.3745/JIPS.2012.8.2.191 - Open Access Since a social network by definition is so diverse, the problem of estimating the preferences of its users is becoming increasingly essential for personalized applications, which range from service recommender systems to the targeted advertising of services. However, unlike traditional estimation problems where the underlying target distribution is stationary; estimating a user's interests typically involves non-stationary distributions. The consequent time varying nature of the distribution to be tracked i…

Ambulatory Blood Pressure Values in the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial (ONTARGET)

2012

In the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial, telmisartan (T; 80 mg daily) and ramipril (R; 10 mg daily) caused similar clinic blood pressure (BP) reductions, with a similar incidence of cardiovascular and renal events. The R+T combination lowered clinic BP somewhat more with no further cardiovascular or renal protection. The aim of this substudy was to see whether these clinic BP changes reflected the changes of 24-hour BP, a BP with a better prognostic value. In 422 patients in whom 24-hour BP monitoring was performed either before or after 6 to 24 months of treatment, demographic and clinical characteristics were similar in the 3 treated groups.…